Journal
CANCER LETTERS
Volume 416, Issue -, Pages 75-86Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.12.014
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Funding
- Indian Institute of Technology Guwahati, Assam, India [BT/P/SG/01]
- UGC
- DST-INSPIRE
- National Medical Research Council of Singapore
- Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore
- National Research Foundation Singapore
- Singapore Ministry of Education under Research Centers of Excellence initiative
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Natural compounds have enormous biological and clinical activity against dreadful diseases such as cancer, as well as cardiovascular and neurodegenerative disorders. In spite of the widespread research carried out in the field of cancer therapeutics, cancer is one of the most prevalent diseases with no perfect treatment till date. Adverse side effects and the development of chemoresistance are the imperative limiting factors associated with conventional chemotherapeutics. For this reason, there is an urgent need to find compounds that are highly safe and efficacious for the prevention and treatment of cancer. Gambogic acid (GA) is a xanthone structure extracted from the dry, brownish gamboge resin secreted from the Garcinia hanbutyi tree in Southeast Asia and has inherent anti-cancer properties. In this review, the molecular mechanisms underlying the targets of GA that are liable for its effective anti-cancer activity are discussed that reveal the potential of GA as a pertinent candidate that can be appropriately developed and designed into a capable anti-cancer drug. (C) 2017 Elsevier B.V. All rights reserved.
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