Journal
CANCER LETTERS
Volume 427, Issue -, Pages 18-27Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.04.006
Keywords
Circular RNA; Back-splicing; MicroRNA sponge; Lung cancer; Biomarker
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Funding
- Fundamental Research Funds for the Central Universities [2015305020202, 2042018kf0025]
- China Postdoctoral Science Foundation [2017M620340]
- National Postdoctoral Program for Innovative Talents [BX201700178]
- Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology [OHIC2017Y02]
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Lung cancer, the leading cause of cancer deaths worldwide, is characterized with malignant cell growth. Advances in next-generation sequencing has helped us further understand RNA and identify novel circular RNAs (circRNAs) that may be useful in the early diagnosis and treatment of lung cancer. Similar to other noncoding RNAs, circRNAs present diverse biological functions in normal and disease states, including various types of cancers. This review focuses mainly on the poorly understood functions of circRNA in lung cancer. This paper also summarizes the recent advances in circRNA biogenesis, analyzes the role of circRNAs in cancers, and discusses the potential mechanisms of circRNAs in lung cancer. (C) 2018 Elsevier B.V. All rights reserved.
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