Journal
CANCER LETTERS
Volume 424, Issue -, Pages 46-69Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.02.030
Keywords
Autophagy; Cancer; Cell death; Oxidative stress; Phytochemical; Therapy
Categories
Funding
- National Institute for Medical Research Development (NIMAD) [940943]
- National Research Institute for Science Policy (NRISP) [1456]
- National Institute for Genetic Engineering and Biotechnology
- Cancer Biology Research Center
- Polish KNOW (Leading National Research Centre) Scientific Consortium Healthy Animal-Safe Food, decision of Ministry of Science and Higher Education [05-1/KNOW2/2015]
- European Union's Seventh Framework Programme for Research, Technological Development, and Demonstration [621364]
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The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy. (C) 2018 Elsevier B.V. All rights reserved.
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