Journal
CANCER CELL
Volume 33, Issue 2, Pages 164-172Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2018.01.007
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Funding
- Ligue Nationale contre le Cancer
- Project National Cancer Association, Lyon Integrated Research Institute in Cancer (LYRIC) [INCa 4664]
- INSERM/CNRS
- ATIP-AVENIR
- Plan cancer
- La Ligue contre le Cancer Nationale et Regionale
- Fondation ARC
- INCa
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Completion of early stages of tumorigenesis relies on the dynamic interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.
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