Journal
CANCER CELL
Volume 34, Issue 1, Pages 21-43Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2018.03.022
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Funding
- NIH [CA154377, ES026845, DK109555, ES023758]
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The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.
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