Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 96, Issue 3, Pages -Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjpp-2017-0157
Keywords
exercise preconditioning; estradiol; stroke; permanent middle cerebral artery occlusion; interleukin 10; matrix metalloproteinase-9
Categories
Funding
- Rafsanjan University of Medical Sciences, Rafsanjan, Iran [9/2331]
Ask authors/readers for more resources
Exercise preconditioning has been shown to be effective in improving behavioral and neuropathological indices after cerebral ischemia. We evaluated the effect of exercise preconditioning, 17 beta-estradiol, and their combination on stroke outcome using an experimental model of stroke in ovariectomized (OVX) mice. OVX mice were randomly assigned to 4 groups as follows: control (stroke), exercise (exercise and stroke), estradiol (17 beta-estradiol and stroke), and exercise+estradiol (exercise and 17 beta-estradiol and stroke). Exercise preconditioning was performed on a treadmill 5 days/week, 40 min/day, at a speed of 18 m/min for 4 weeks. 17 beta-estradiol was gavaged (40 mu g/kg per day) for 4 weeks. Stroke was induced by permanent middle cerebral artery occlusion (pMCAO), and neurological deficits were evaluated 1, 2, and 7 days after stroke. Then, the serum concentrations of matrix metalloproteinase-9 (MMP-9) and interleukin-10 (IL-10) and infarct volumes were assessed. Exercise preconditioning and 17 beta-estradiol induced a better outcome compared with the control ischemic mice, which was manifested by decrease in MMP-9, increase in IL-10, diminished infarct volume, and improved neurological deficits. Concomitant administration of 17 beta-estradiol and exercise also significantly improved these parameters. Exercise preconditioning or administration of 17 beta-estradiol alone or in combination before pMCAO induced significant neuroprotection in OVX mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available