Unresolved Issues that Remain in Molecular Self-Assembly

Two unresolved issues in molecular self-assembly are discussed. Firstly, a novel method for the investigation of molecular self-assembly processes (QASAP: quantitative analysis of self-assembly process) is introduced and recent progress in the understanding of coordination self-assembly processes revealed by QASAP is described. Secondary, a challenge to the construction of discrete molecular self-assemblies that are formed with the aid of weak, nondirectional molecular interactions (such as van der Waals interactions) and the hydrophobic effect is discussed. In the course of the development of hexameric cube-shaped molecular self-assemblies (nanocubes) from gear-shaped amphiphiles (GSAs) in water, a design principle of hydrophobic surface engineering and a novel strategy for the construction of thermally stable discrete assemblies, molecular 'Hozo', are presented.