Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 164, Issue 6, Pages 775-779Publisher
SPRINGER
DOI: 10.1007/s10517-018-4078-x
Keywords
endotheliocytes; induced pluripotent stem cells; sepsis; sphingosine-1-phosphate
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Funding
- KAKENHI grant from the Japan Society for the Promotion of Science [25861727]
- Grants-in-Aid for Scientific Research [25861727] Funding Source: KAKEN
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The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.
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