Journal
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
Volume 101, Issue 2, Pages 205-213Publisher
SPRINGER
DOI: 10.1007/s00128-018-2384-7
Keywords
Binary mixtures; Diclofenac; Cadmium; Desmodesmus subspicatus; Normalization method
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Funding
- Faculty of Chemistry (Brno University of Technology) - Ministry of Education, Youth and Sports of the Czech Republic [FCH-S-18-5331, LO1203]
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Algal test using chlorococcal algae Desmodesmus subspicatus was used to determine single acute toxicity of either diclofenac or cadmium and to assess acute toxicity of their binary mixtures. The test confirmed significant acute toxicity of both diclofenac and cadmium; diclofenac with acute toxicity E(r)C50 60.44 +/- 0.20 mg/L and cadmium with acute toxicity E(r)C50 2.14 +/- 0.02 mg/L. This study of acute toxicity of binary cadmium-diclofenac mixtures confirmed their negative effects on aquatic producers and it also proved influence of the above substances on acute toxicity of their mixtures. Normalization method was applied to predict acute toxicity of binary mixtures composed of chemicals with significantly different acute toxicities. Normalization method used molar ratio (R) of chemicals in binary mixtures as their composition descriptor.
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