Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 181, Issue 2, Pages 229-233Publisher
WILEY
DOI: 10.1111/bjh.15174
Keywords
chronic lymphocytic leukaemia; complex karyotype; gene expression profile; overall survival; time to first treatment
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Funding
- Fondo di Ateneo per la Ricerca of the University of Ferrara
- Programma Ricerca Regione Universita, University of Ferrara
- Programmi di Ricerca di Rilevante Interesse Nazionale (PRIN)
- Ricerca Finalizzata Ministero della Sanita [RF-2011-02349712]
- Ministero dell'Istruzione, dell'Universita e della Ricerca PRIN
- BEAT Leukemia Foundation Milan Italy
- AIL Ferrara
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Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 733% of 90 CLL patients with CK (i.e. 3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P=0025) and a shorter time to first treatment (P=0043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics.
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