Journal
BRIEFINGS IN BIOINFORMATICS
Volume 20, Issue 6, Pages 1957-1971Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbx170
Keywords
precision medicine; metabolomics; metabolite profiling; NMR; mass spectrometry; GC-MS; LC-MS; bioinformatics
Funding
- NIH NIAID [5R01AI111962-02]
- NIH NIDDK [DK109524-01]
Ask authors/readers for more resources
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small group or even individual patients based on their genetics, environment and lifestyle. Precision medicine relies heavily on developments in systems biology and omics disciplines, including metabolomics. Combination of metabolomics with sophisticated bioinformatics analysis and mathematical modeling has an extreme power to provide a metabolic snapshot of the patient over the course of disease and treatment or classifying patients into subpopulations and subgroups requiring individual medical treatment. Although a powerful approach, metabolomics have certain limitations in technology and bioinformatics. We will review various aspects of metabolomics technology and bioinformatics, from data generation, bioinformatics analysis, data fusion and mathematical modeling to data management, in the context of precision medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available