Journal
BRAIN TUMOR PATHOLOGY
Volume 35, Issue 2, Pages 57-61Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10014-017-0307-7
Keywords
Aggressive adenomas; Nonfunctioning adenomas; Pituitary adenomas; Transcription factor; WHO classification
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WHO classification of pituitary adenomas was revised in 2017. The two major and significant changes are discussed. (1) The new classification focuses on adenohypophysial-cell lineage for the designation of adenomas, and thus, assessment of pituitary transcription factors is recommended. Its appropriate use has a complementary role in obtaining an accurate diagnosis, particularly in hormone-negative adenomas. Subclassification of nonfunctioning adenomas was revised accordingly and, consequently, null cell adenomas became quite rare. (2) Atypical adenoma, a previous category, was eliminated due to the poor reproducibility and predictive value. Assessment of tumor proliferation marker and other clinical parameters such as invasion are recommended to predict aggressiveness. High-risk adenomas are those with rapid growth, radiological invasion, and a high Ki-67 proliferation index, whereas some special adenoma subtypes commonly show aggressive behavior.
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