Journal
BRAIN STIMULATION
Volume 11, Issue 5, Pages 1024-1032Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2018.06.004
Keywords
Transcranial direct current stimulation; Neuromodulation; Transcranial magnetic stimulation; Electroencephalogram; Dorsolateral prefrontal cortex
Categories
Funding
- German Federal Ministry for Economic Affairs and Energy of EXIST Transfer of Research Grant [03EFJBW169]
- Clinician Scientist Program at the Faculty of Medicine at the gs2:University of Tubingen
- DFG [ZI 542/7-1]
- Federal Ministry of Education and Research of Germany through the MOTOR-BIC project (BMBF) [13GW0053A]
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Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with potential for cost-effective therapeutic neuromodulation. Although positive therapeutic effects were found by stimulating the dorsolateral prefrontal cortex (DLPFC), few studies have investigated physiological effects of DLPFC-tDCS. Objectives: To investigate effects of tDCS with different parameter settings applied to the left DLPFC on cortical responses, measured by resting-state electroencephalography (rs-EEG) and transcranial magnetic stimulation (TMS)-evoked/induced EEG responses. Methods: 22 healthy subjects underwent 5 tDCS sessions with different tDCS parameter settings in a double-blinded randomized crossover design (1: 1.5 mA, anode left-DLPFC, cathode right-DLPFC; 2: 1.5 mA, cathode left-DLPFC, anode right-DLPFC; 3: 0.5 mA, anode left-DLPFC, cathode right-DLPFC; 4: 1.5 mA, anode left-DLPFC, cathode left deltoid muscle; 5: sham stimulation). Rs-EEG and TMS-EEG were recorded before and after tDCS. Results: Rs-EEG power spectrum analysis showed no difference comparing baseline with post stimulation in any of the tDCS conditions. TMS-EEG evoked potential amplitude decreased in parietal cortex after 1.5mA left-DLPFC anodal tDCS, and TMS-induced gamma and theta oscillations decreased after all conditions using left-DLPFC anodal tDCS. Left-DLPFC cathodal tDCS did not lead to significant change. None of the post-intervention changes was different when comparing the effects across conditions, including sham. Conclusions: Our study does not provide evidence that a single tDCS session results in significant changes in rs-EEG, using the current stimulation parameters. Significant changes in EEG responses to TMS pulses were observed following the anodal 1.5 mA tDCS interventions, although these changes were not statistically significant in a group comparison. (c) 2018 Elsevier Inc. All rights reserved.
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