Journal
BRAIN RESEARCH BULLETIN
Volume 139, Issue -, Pages 16-20Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2018.01.013
Keywords
Phox2b; Parafacial respiratory group; EYFP; Calcium imaging; Transgenic rat
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Funding
- KAKENHI on Innovative Areas (Comprehensive Brain Science Network) from MEXT
- KAKENHI [16K07003, 25430012]
- Program for the Strategic Research Foundation at Private Universities (Showa University School of Medicine)
- Program for the Strategic Research Foundation at Private Universities (Jichi Medical University)
- Grants-in-Aid for Scientific Research [16K11488, 17K19775, 16K07003, 15K01835, 15H05050, 26293397] Funding Source: KAKEN
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The parafacial respiratory group (pFRG) surrounding the ventrolateral part of the facial motor nucleus is one of respiratory rhythm generators that consists of pre-inspiratory (Pre-I) neurons. Previous studies showed that most of the Pre-I neurons locating in the Phox2b cluster of the rostral ventral medulla were also Phox2b positive and intrinsically CO2 sensitive. However, it is not clear what percentage of Phox2b-expressing cells in the pFRG of the ventral medulla are Pre-I neurons. To address this issue, we analyzed the activity of Phox2b-positive cells by calcium imaging using a confocal laser microscope in transgenic rats in which Phox2b-positive cells expressed EYFP. We found that more than 60% of the EYFP/Phox2b-positive cells showed Pre-I neuron-like rhythmic burst activity in the parafacial region of newborn rat.
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