Journal
BRAIN RESEARCH
Volume 1698, Issue -, Pages 70-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2018.06.023
Keywords
Aldosterone; Sodium ingestion; Sodium excretion; Baroreflex; HDS2 neurons
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Funding
- Conselho Nacional de Pesquisa (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2013/00026-0, FAPESP 2015/23467-7, 2018/04134-5]
- PROPE-UNESP
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Aldosterone infusion into the 4th ventricle (4th V), upstream the nucleus of the solitary tract (NTS), produces strong 0.3 M NaCl intake. In the present study, we investigated whether aldosterone infusion into the 4th V activates HSD2 neurons, changes renal excretion, or alters blood pressure and cardiovascular reflexes. Chronic infusion of aldosterone (100 ng/h) into the 4th V increased daily 0.3 M NaCl intake (up to 44 +/- 10, vs. vehicle: 5.6 +/- 3.4 ml/24 h) and also c-Fos expression in HSD2 neurons in the NTS and in non-HSD2 neurons in the NTS. Natriuresis, diuresis and positive sodium balance were present in rats that ingested 0.3 M NaCl, however, renal excretion was not modified by 4th V aldosterone in rats that had no access to NaCl. 4th V aldosterone also reduced baroreflex sensitivity (-2.8 +/- 0.5, vs. vehicle: -5.1 +/- 0.9 bpm/mmHg) in animals that had sodium available, without changing blood pressure. The results suggest that sodium intake induced by aldosterone infused into the 4th V is associated with activation of NTS neurons, among them the HSD2 neurons. Aldosterone infused into the 4th V in association with sodium intake also impairs baroreflex sensitivity, without changing arterial pressure. (C) 2018 Elsevier B.V. All rights reserved.
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