Journal
BONE
Volume 119, Issue -, Pages 1-7Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2018.07.012
Keywords
Hematopoiesis; Stem cells; Aging; Bone marrow; Microenvironment
Categories
Funding
- National Heart, Lung, and Blood Institute [F31 HL131184]
- National Institutes of Allergy and Infectious Diseases [U01 AI107276]
- National Cancer Institute [R01 CA166280]
- National Institute on Aging [R01 AG046293]
- Wilmot Cancer Institute
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Hematopoiesis in land dwelling vertebrates and marine mammals occurs within the bone marrow, continually providing mature progeny over the course of an organism's lifetime. This conserved dependency highlights the critical relationship between these two organs, yet the skeletal and hematopoietic systems are often thought of as separate. In fact, data are beginning to show that skeletal disease pathogenesis influences hematopoiesis and viceversa, offering novel opportunities to approach disease affecting bone and blood. With a growing global population of aged individuals, interest has focused on cell autonomous changes in hematopoietic and skeletal systems that result in dysfunction. The purpose of this review is to summarize the literature on aging effects in both fields, and provide critical examples of organ cross-talk in the aging process.
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