Journal
BONE
Volume 109, Issue -, Pages 12-21Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2017.09.019
Keywords
Ectopic bone; Inflammation; Bone morphogenetic protein receptors
Categories
Funding
- NIH/National Institute of General Medical Sciences [K08GM109105-0]
- NIH/National Institute of Health [RO1 GM123069, R01 AR071379]
- Plastic Surgery Foundation
- Association for Academic Surgery Roslyn Award
- American Association for the Surgery of Trauma Research & Education Foundation Scholarship
- American Association of Plastic Surgery Academic Scholarship
- American College of Surgeons Clowes Award
- American Association of Plastic Surgeons Pilot Award
- International FOP Association
- Department of Defense [W81XWH-17-1-0655, W81XWH-16-2-0051]
- NIH/National Institute of Dental and Craniofacial Research [R01 DE020843]
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Tissue regeneration following acute or persistent inflammation can manifest a spectrum of phenotypes ranging from the adaptive to the pathologic. Heterotopic Ossification (HO), the endochondral formation of bone within soft-tissue structures following severe injury serves as a prominent example of pathologic differentiation; and remains a persistent clinical issue incurring significant patient morbidity and expense to adequately diagnose and treat. The pathogenesis of HO provides an intriguing opportunity to better characterize the cellular and cell-signaling contributors to aberrant differentiation. Indeed, recent work has continued to resolve the unique cellular lineages, and causative pathways responsible for ectopic bone development yielding promising avenues for the development of novel therapeutic strategies shown to be successful in analogous animal models of HO development. This review details advances in the understanding of HO in the context of inciting inflammation, and explains how these advances inform the current standards of diagnosis and treatment. (C) 2017 Elsevier Inc. All rights reserved.
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