Journal
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
Volume 25, Issue 2, Pages 129-148Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hmbci-2016-0005
Keywords
androgens; endometrial cancer; gonadotropin-releasing hormones; oestrogen; polycystic ovarian syndrome; progesterone
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Funding
- Wellbeing of Women [RG1073, RG1487, RTF510] Funding Source: researchfish
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Endometrial cancer (EC) is the commonest gynaecological cancer in the Western World with an alarmingly increasing incidence related to longevity and obesity. Ovarian hormones regulate normal human endometrial cell proliferation, regeneration and function therefore are implicated in endometrial carcinogenesis directly or via influencing other hormones and metabolic pathways. Although the role of unopposed oestrogen in the pathogenesis of EC has received considerable attention, the emerging role of other hormones in this process, such as androgens and gonadotropin-releasing hormones (GnRH) is less well recognised. This review aims to consolidate the current knowledge of the involvement of the three main endogenous ovarian hormones (oestrogens, progesterone and androgens) as well as the other hormones in endometrial carcinogenesis, to identify important avenues for future research.
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