Journal
NATURE REVIEWS IMMUNOLOGY
Volume 16, Issue 2, Pages 102-111Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2015.10
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Funding
- US National Institutes of Health [RO1AI066232, R01AI074699, R01AR40072, P30AR053495, R21AR063942, T32AI07019, F31AG07777]
- Howard Hughes Medical Institute
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Following infection, T cells differentiate into a heterogeneous population of effector T cells that can mediate pathogen clearance. A subset of these effector T cells possesses the ability to survive long term and mature into memory T cells that can provide long-term immunity. Understanding the signals that regulate the development of memory T cells is crucial to efforts to design vaccines capable of eliciting T cell-based immunity. CD4(+) T cells are essential in the formation of protective memory CD8(+) T cells following infection or immunization. However, until recently, the mechanisms by which CD4(+) T cells act to support memory CD8(+) T cell development following infection were unclear. Here, we discuss recent studies that provide insight into the multifaceted role of CD4(+) T cells in the regulation of memory CD8(+) T cell differentiation.
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