Journal
NATURE REVIEWS CANCER
Volume 16, Issue 2, Pages 110-120Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc.2015.21
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Funding
- Breast Cancer Now, London, UK
- Cancer Research UK
- Wellcome Trust, London, UK
- Breast Cancer Research Foundation, New York, USA
- Komen Foundation, Dallas, Texas, USA
- University of California, San Francisco, USA
- Cancer Research UK [14276] Funding Source: researchfish
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Over the past 20 years, there has been considerable progress in our understanding of the biological functions of the BRCA1 and BRCA2 cancer susceptibility genes. This has led to the development of new therapeutic approaches that target tumours with loss-of-function mutations in either BRCA1 or BRCA2. Tumours that share molecular features of BRCA-mutant tumours - that is, those with 'BRCAness' - may also respond to similar therapeutic approaches. Several paradigm shifts require a reassessment of the concept of BRCAness, how this property is assayed and its relevance to our understanding of tumour biology and the treatment of cancer.
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