Journal
BMC MICROBIOLOGY
Volume 18, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12866-018-1166-z
Keywords
Carbapenemase-producing Enterobacteriaceae; Pediatrics; Mexico; NDM-1; KPC-2; OXA-48; OXA-232
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Funding
- National Council for Science and Technology (Consejo Nacional de Ciencia y Tecnologia) through the Health Sector Fund (Fondo Sectorial de Salud FOSSIS) [2012-1-181041]
- Federal Budget Research Funds (Fondos de Presupuesto Federal para Investigacion) of the INP
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Background: Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epidemiological, and molecular characteristics of seven consecutive cases in a third-level pediatric hospital in Mexico City over a four-month period during 2016. Results: The Enterobacteriaceae identified were three Escherichia coli strains (producing OXA-232, NDM-1 and KPC-2), two Klebsiella pneumoniae strains (producing KPC-2 and NDM-1), one Klebsiella oxytoca strain producing OXA-48 and one Enterobacter cloacae strain producing NDM-1. The majority of patients had underlying disesases, three were immunocompromised, and three had infections involved the skin and soft tissues. Half patients died as a result of CPE infection. Conclusions: This study represents the first report of E coil ST131-O25b clone producing NDM-1 in Latin America. In addition, this study is the first finding of K oxytoca producing OXA-48 and E. coli producing OXA-232 in Mexican pediatric patients.
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