Journal
BMC BIOINFORMATICS
Volume 19, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12859-018-2249-4
Keywords
Predict succinylation sites; Multiple features; Grey pseudo amino acid composition; Information gain; SVM; Ensemble learning algorithm
Categories
Funding
- National Natural Science Foundation of China [61403077]
- China Postdoctoral Science Foundation [2014 M550166, 2015 T80285]
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Background: Lysine succinylation is a new kind of post-translational modification which plays a key role in protein conformation regulation and cellular function control. To understand the mechanism of succinylation profoundly, it is necessary to identify succinylation sites in proteins accurately. However, traditional methods, experimental approaches, are labor-intensive and time-consuming. Computational prediction methods have been proposed recent years, and they are popular because of their convenience and high speed. In this study, we developed a new method to predict succinylation sites in protein combining multiple features, including amino acid composition, binary encoding, physicochemical property and grey pseudo amino acid composition, with a feature selection scheme (information gain). And then, it was trained using SVM (Support Vector Machine) and an ensemble learning algorithm. Results: The performance of this method was measured with an accuracy of 89.14% and a MCC (Matthew Correlation Coefficient) of 0.79 using 10-fold cross validation on training dataset and an accuracy of 84.5% and a MCC of 0.2 on independent dataset. Conclusions: The conclusions made from this study can help to understand more of the succinylation mechanism. These results suggest that our method was very promising for predicting succinylation sites.
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