Journal
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 125, Issue 10, Pages 1280-1286Publisher
WILEY
DOI: 10.1111/1471-0528.15312
Keywords
Myelomeningocele; open fetal surgery; perinatal outcome; spina bifida
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Objective Describe outcomes of open fetal surgery for myelomeningocele (MMC) repair in two Brazilian hospitals and the impact of surgical experience on outcome. Design Retrospective cohort study. Setting Sao Paulo, Brazil. Population 237 pregnant women carrying a fetus with an open spinal defect. Methods Surgical details, and maternal and fetal outcomes collected from all patients. Main outcome measures Analysis of surgical and perinatal outcome parameters. Results Total surgical time was 119 +/- 7.6 minutes. Preterm labour occurred in 24.2%, premature rupture of membranes in 26.7%, placental abruption in 0.8%, need for a blood transfusion at delivery in 2.1%, and dehiscence at the repair site in 2.5%. Reversal of hindbrain herniation at birth occurred in 71.4%. There were no maternal deaths or severe maternal morbidities. The failure rate with the patient anaesthetised was 0.42% and perinatal mortality was 2.1% (three intrauterine demises and two neonatal deaths). Comparing results from our study in the first 3 years with the last 3 years demonstrated improvement in the total surgical time (121.2 +/- 6.4 versus 118.5 +/- 8.2 minutes, P = 0.005) and an increase in reversal of hindbrain herniation at birth (64.0 versus 77.1%, P = 0.042). Conclusion Our open fetal surgical approach for MMC was effective and results were comparable to past studies. Improvements in surgical performance and perinatal outcome increased as the surgical team became more familiar with the procedure.
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