Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 115, Issue 9, Pages 2139-2147Publisher
WILEY
DOI: 10.1002/bit.26738
Keywords
alkane; alkene; fatty acid; fatty alcohol; hydrocarbon; yeast
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Funding
- Fundamental Research Funds for the Central Universities [buctrc201801]
- Natural Science Foundation of Beijing Municipality [5182017]
- Beijing Advanced Innovation Center for Soft Matter Science and Engineering
- Beijing University of Chemical Technology
- Novo Nordisk Foundation
- Knut and Alice Wallenberg Foundation
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Fatty acid-derived hydrocarbons attract increasing attention as biofuels due to their immiscibility with water, high-energy content, low freezing point, and high compatibility with existing refineries and end-user infrastructures. Yeast Saccharomyces cerevisiae has advantages for production of fatty acid-derived hydrocarbons as its native routes toward fatty acid synthesis involve only a few reactions that allow more efficient conversion of carbon substrates. Here we describe major biosynthetic pathways of fatty acid-derived hydrocarbons in yeast, and summarize key metabolic engineering strategies, including enhancing precursor supply, eliminating competing pathways, and expressing heterologous pathways. With recent advances in yeast production of fatty acid-derived hydrocarbons, our review identifies key research challenges and opportunities for future optimization, and concludes with perspectives and outlooks for further research directions.
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