Journal
BIOTECHNOLOGY ADVANCES
Volume 36, Issue 3, Pages 666-681Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.01.009
Keywords
(-)-Epicatechin; Flavonoids; Flavanols; Hypertension; Brain disorders; Endothelial dysfunction; Neuroprotection; Behaviour; Superoxide; Nitric oxide
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Funding
- Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic [2/0160/17]
- Slovak Research and Development Agency [APVV-16-0263]
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Recent studies have suggested that certain (-)-epicatechin-containing foods have a blood pressure-lowering capacity. The mechanisms underlying (-)-epicatechin action may help prevent oxidative damage and endothelial dysfunction, which have both been associated with hypertension and certain brain disorders. Moreover, (-)-epicatechin has been shown to modify metabolic profile, bloods rheological properties, and to cross the blood-brain barrier. Thus, (-)-epicatechin causes multiple actions that may provide unique synergy beneficial for cardiovascular and neuropsychological health. This review summarises the current knowledge on the biological actions of (-)-epicatechin, related to cardiovascular and brain functions, which may play a remarkable role in human health and longevity.
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