Journal
BIOSENSORS & BIOELECTRONICS
Volume 99, Issue -, Pages 493-499Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.08.034
Keywords
Label-free immunosensor; Photoelectrochemistry; CEA; WO3@BiOI@CdS hybrid structure
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Funding
- National Natural Science Foundation of China [21405059, 21575047]
- Natural Science Foundation of Shandong Province [ZR2016JL013, ZR2014BL024]
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In this work, a label-free photoelectrochemical (PEC) immunosensor for the detection of carcino embryonic antigen (CEA) was developed based on CdS nanowires (NWs) sensitized WO3@BiOI heterostructure. The construction procedure of ITO/WO3@BIOI@CdS electrode was done by dipping the WO3@BiOI modified indium-tin oxide (ITO) electrode interchangeably into [Cd(NH3)(4)](2+) and S2- solution for several times. Then the ITO/WO3@BiOI@CdS electrode was used as a matrix for the subsequent immobilization of CEA antibody (Ab). The obtained label-free PEC immunosensor showed an excellent PEC performance toward CEA detection. Under optimal conditions, the PEC immunosensor have a sensitive response to CEA in a liner range of 0.01 ng/ mL to 50 ng/mL with a detection limit of 3.2 pg/mL. The proposed PEC immunosensor exhibited good stability, high sensitivity as well as reproducibility and storage stability. Moreover, the obtained PEC immunosensor also showed a satisfied result in human serum sample analysis.
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