Journal
BIOSENSORS & BIOELECTRONICS
Volume 111, Issue -, Pages 27-33Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.03.061
Keywords
Carbon nanotube; Carbon paste electrode; Imprinted polymer; Trimipramine; Voltammetric sensor; Nanoparticles
Categories
Funding
- Institute of Electrochemistry, Tehran University, Iran
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A novel carbon nanocomposite paste electrode was prepared and used as a voltammetric sensor for ultratrace determination of trimipramine (TRI) which currently used for the treatment of psychiatric disorders. For this aim, nanoparticles of molecularly imprinted polymer (MIP), synthesized by precipitation polymerization method, and multi-walled carbon nanotubes (MWCNTs) were embedded in a nanocomposite paste electrode. The nanocomposite mixing style demonstrated a significant influence on the final electrode performance. The sensor exhibited linear response range of 1.0 x 10(-10)-2.5 x 10(-8) mol L-1 and very high sensitivity of 2131 mu A mu mol L-1. The lower detection limit of the sensor was calculated to be 4.5 x 10(-11) mol L-1 (S/N = 3). This sensor was applied successfully for highly selective determination of TRI in pharmaceutical formulations, urine and serum samples without applying any sample pretreatment.
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