Journal
BIOSENSORS & BIOELECTRONICS
Volume 111, Issue -, Pages 47-51Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.03.052
Keywords
Hollow dendritic nanostructures; Alloyed nanocrystals; Label-free immunosensor; L-Proline; Prostate specific antigen
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Funding
- National Natural Science Foundation of China [21475118, 21675093]
- Foundation of Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, Qingdao University of Science and Technology [SATM201703, STAM201804]
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Herein, well-defined hollow dendritic AuPtAg alloyed nanocrystals (ANCs) were synthesized by a simple L-proline-mediated one-pot aqueous method. More importantly, the synthesized hollow dendritic architectures provide a suitable platform for immobilization of anti-prostate specific antigen (PSA). The resultant label-free immunosensor exhibited the improved performance for highly sensitive detection of PSA based on the enhanced catalytic currents of K-3[Fe(CN)(6)] as a signal probe. Impressively, the immunosensor showed the wide linear range of 0.05-50 ng mL(-1) and low detection limit of 0.017 ng mL(-1) under optimal conditions for the assay of PSA, couple with the improved stability, reproducibility and selectivity. It provides a promising platform for clinical research and diagnosis.
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