Journal
BIOSENSORS & BIOELECTRONICS
Volume 110, Issue -, Pages 89-96Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.03.019
Keywords
Laser-scribed graphene; Copper nanoparticles; Electrodeposition; Flexible conductive substrates; Glucose sensor; Flexible biosensors
Categories
Funding
- National Natural Science Foundation of China [51602310]
- Fujian Provincial Department of Science and Technology [2018H01010111, 2018H01010112, 2016H0047, 2016T3011, 2016T3027, 2016T3031, 2016T3022, 2018T3010]
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Flexible and implantable glucose biosensors are emerging technologies for continuous monitoring of blood glucose of diabetes. Developing a flexible conductive substrates with high active surface area is critical for advancing the technology. Here, we successfully fabricate a flexible and highly sensitive nonenzymatic glucose by using DVD-laser scribed graphene (LSG) as a flexible conductively substrate. Copper nanoparticles (Cu-NPs) are electrodeposited as the catalyst. The LSG/Cu-NPs sensor demonstrates excellent catalytic activity toward glucose oxidation and exhibits a linear glucose detection range from 1 mu M to 4.54 mM with high sensitivity (1.518 mA mM(-1)cm(-2)) and low limit of detection (0.35 01). Moreover, the LSG/Cu-NPs sensor shows excellent reproducibility and long-term stability. It is also highly selective toward glucose oxidation under the presence of various interfering species. Excellent flexing stability is also demonstrated by the LSG/Cu-NPs sensor, which is capable of maintaining 83.9% of its initial current after being bent against a 4-mm diameter rod for 180 times. The LSG/Cu-NPs sensor shows great potential for practical application as a nonenzymatic glucose biosensor. Meanwhile, the LSG conductive substrate provides a platform for the developing next-generation flexible and potentially implantable bioelectronics and biosensors.
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