Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 82, Issue 9, Pages 1647-1651Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2018.1482195
Keywords
Exopolysaccharide; Leuconostoc mesenteroides; dendritic cell; RALDH; adjuvant
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Funding
- Tojuro Iijima Foundation for Food Science and Technology
- Sugiyama Sangyo Kagaku Kenkyusho
- Japan Agency for Medical Research and Development [JP17ek0410032s0102, JP17ak0101068h0001, JP17gm1010006s0101]
- Japan Society for the Promotion of Science [JP18964480, JP18K17997, JP18J00556]
- Canon Foundation
- Food Science Institute Foundation (Ryoushoku Kenkyukai)
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This study evaluated the immunostimulative effect on bone marrow-derived dendritic cells (DCs) of adjuvant-active exopolysaccharide (EPS) produced by Leuconostoc mesenteroides strain NTM048. EPS stimulation increased IL-6, IL-10, IL-12, and retinal dehydrogenase (RALDH) gene expression levels and induced retinoic acid-synthesizing RALDH-active DCs, which play a crucially important role in controlling adaptive immune responses in mucosa.
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