Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 82, Issue 2, Pages 207-215Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2017.1415750
Keywords
Flavonoid; prenyl group; prenylation; biological activity; bioavailability
Categories
Funding
- Program for the Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry (Japan)
- JSPS KAKENHI [26892020, 16K12721]
- Grants-in-Aid for Scientific Research [26892020, 16K12721] Funding Source: KAKEN
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Flavonoids are distributed across the plant kingdom and have attracted substantial attention owing to their potential benefits for human health. Several studies have demonstrated that flavonoids prenylation enhances various biological activities, suggesting an attractive tool for developing functional foods. This review provides an overview of the current knowledge on how prenylation influences the biological activity and bioavailability of flavonoids. The enhancement effect of prenylation on the biological activities of dietary flavonoids in mammals was demonstrated by comparing the effect of 8-prenyl naringenin (8PN) with that of parent naringenin in the prevention of disuse muscle atrophy in mice. This enhancement results from higher muscular accumulation of 8PN than naringenin. As to bioavailability, despite the lower absorption of 8-prenyl quercetin (8PQ) compared with quercetin, higher 8PQ accumulation was found in the liver and kidney. These data imply that prenylation interferes with the elimination of flavonoids from tissues.
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