Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 82, Issue 4, Pages 547-553Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2017.1401912
Keywords
Obesity; metabolic syndrome; chronic inflammation; brown adipocyte; thermogenesis
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Funding
- Ministry of Education, Culture, Sport, Science and Technology of Japan [22228001, 16H02551, 16K14927]
- Research Project on Development of Agricultural Products and Foods with Health-promoting benefits ( NARO) Japan [2013-A-10]
- Grants-in-Aid for Scientific Research [16H02551, 16K14927] Funding Source: KAKEN
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Obesity is a key factor in metabolic syndrome. The study of metabolic syndrome focuses on the anti-weight gain properties of physiological mechanisms and food components. Abnormal energy metabolism is a major risk factor of metabolic syndrome. Chronic inflammation is a feature of obesity; cytokines from hypertrophied adipocytes cause inflammation in both adipose tissue and blood vessels, resulting in symptoms of metabolic syndrome. Tumor necrosis factor- causes insulin resistance in adipocytes and regression of brown adipocytes, resulting in abnormal energy metabolism. Functional foods can serve as a strategy for prevention and treatment of obesity linked with metabolic processes in white and brown adipose tissues. Diet-induced thermogenesis caused by certain food components stimulates burning of stored fat within adipose tissues. A mechanistic understanding of dietary thermogenesis via the sympathetic nerve system will prove valuable for the development of precise strategies for the practical prevention of metabolic syndrome.
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