Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 51, Issue 1, Pages 43-52Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10409238.2015.1117055
Keywords
DNA mismatch repair; exonucleolytic proofreading; genomic ribonucleotide; mutation; polymerase; replication fork
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Funding
- Division of Intramural Research of the NIH, NIEHS [Z01 ES065070]
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The eukaryotic nuclear genome is replicated asymmetrically, with the leading strand replicated continuously and the lagging strand replicated as discontinuous Okazaki fragments that are subsequently joined. Both strands are replicated with high fidelity, but the processes used to achieve high fidelity are likely to differ. Here we review recent studies of similarities and differences in the fidelity with which the three major eukaryotic replicases, DNA polymerases , , and , replicate the leading and lagging strands with high nucleotide selectivity and efficient proofreading. We then relate the asymmetric fidelity at the replication fork to the efficiency of DNA mismatch repair, ribonucleotide excision repair and topoisomerase 1 activity.
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