Journal
BIOPHYSICAL JOURNAL
Volume 115, Issue 1, Pages 3-8Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2018.05.023
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Funding
- University of Michigan Protein Folding Diseases Initiative
- National Institutes of Health [K12 GM111725]
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Cellular condensates-phase-separated concentrates of proteins and nucleic acids-provide organizational structure for biochemistry that is distinct from membrane-bound compartments. It has been suggested that one major function of cellular condensates is to accelerate biochemical processes that are normally slow or thermodynamically unfavorable. Yet, the mechanisms leading to increased reaction rates within cellular condensates remain poorly understood. In this article, we highlight recent advances in microdroplet chemistry that accelerate reaction rates by many orders of magnitude as compared to bulk and suggest that similar mechanisms may also affect reaction kinetics in cellular condensates.
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