Journal
BRAIN CONNECTIVITY
Volume 6, Issue 2, Pages 169-185Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/brain.2015.0345
Keywords
aging; default mode network; executive control network; functional connectivity; functional magnetic resonance imaging; salience network
Categories
Funding
- Singapore Ministry of Education AcRF Tier 1 grant [RG41/08]
- Singapore Ministry of Education Academic Research Fund Tier 2 [MOE2012-T2-2-130]
- Young Investigator Award at the National University of Singapore [NUSYIA FY10 P07]
- Singapore Ministry of Health's National Medical Research Council (NMRC) [NMRC/CBRG/0039/2013]
- NTU Humanities and Social Sciences postdoctoral fellowship
Ask authors/readers for more resources
Aging has been associated with decreased intra- and internetwork connectivity during rest and task. Recent work has shown the influential role of the salience network over the default mode network (DMN) and executive control network (ECN). This study comprehensively investigates age-related changes in intra- and internetwork connectivity and effective connectivity between the DMN, ECN, and salience network across the adult life span. Two hundred ten participants completed a working memory task, an inhibition task, and a resting-state functional magnetic resonance imaging scan. Networks were extracted using independent component analysis; then, regression analyses and t-tests between three age groups, 21-40 (younger), 41-60 (middle), and 61-80 (older), were conducted. Older age was associated with decreased intranetwork connectivity. Functional network connectivity analyses revealed older age was associated with increased internetwork connectivity between the salience network and the ECNs and DMNs. In both cases, the effects were more pronounced in the tasks compared to resting state. Granger causality analyses indicated the salience network was influenced by the DMN and ECN in all age groups during both tasks, but not rest. However, middle adults showed increased influence from the salience network to the right ECN compared to younger adults during the flanker task. Taking everything into account, these findings indicate the role of the salience network changes over the life span, which may have implications for the early detection of pathophysiology in older adults.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available