Journal
MOSCOW UNIVERSITY CHEMISTRY BULLETIN
Volume 71, Issue 2, Pages 127-133Publisher
ALLERTON PRESS INC
DOI: 10.3103/S002713141602005X
Keywords
alginate; chitosan; protein encapsulation; ionotropic gelation; layer-by-layer adsorption; mucoadhesive drug delivery systems
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The properties of protein-containing micro- and nanoparticles that were produced from alginate and chitosan using the methods of layer-by-layer polyelectrolyte adsorption and ionotropic gelation have been compared. The encapsulation efficiency of proteins (aprotinin, interferon, and human insulin), the size and zeta-potential of the particles, the mucin binding, and the protein release under physiological conditions have been studied. The prospects for the possible mucosal application of the particles are discussed.
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