Journal
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
Volume 6, Issue 3, Pages 239-245Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.1016/j.apjtb.2015.12.010
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Objective: To determine the total phenolic and flavonoid contents, antioxidant and antimicrobial activities of methanolic leaf extracts of ten Algerian fig (Ficus carica L.) varieties (uniferous, biferous and caprifig tree). Methods: Phenolics were extracted by Soxhlet method and analyzed by the Folin Ciocalteu colorimetric method. Flavonoids were determined by aluminum trichloride assay and the antioxidant capacity was determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. The antimicrobial activity was studied with the disc diffusion method and a macrodilution broth method was used to determine the minimal inhibitory concentrations and minimal lethal concentrations. Results: The mean extract yield was 14.10% +/- 0.66% (n = 10). Leaf extract of biferous followed by uniferous varieties had the highest total phenolic contents [(52.296 +/- 5.232) and (48.973 +/- 2.015) mg gallic acid equivalent/g of dry plant extract respectively], flavonoids [(14.388 +/- 0.333) and (14.136 +/- 1.082) mg quercetin equivalent/g of dry plant extract] and antioxidant capacity [IC50 (798.754 +/- 108.590) and (825.004 +/- 110.835) mg/mL]. Antioxidant capacity of fig leaves was significantly correlated with phenolic contents (r = 0.748). These extracts showed bactericidal activity and moderate antifungal activity, and the minimal inhibitory concentrations and minimal lethal concentrations were determined on Bacillus cereus and Staphylococcus aureus. Conclusions: All tested extracts contain phenolic compounds and exhibited an antioxidant activity and an antimicrobial effect against Gram-positive and Gram-negative bacteria. Further researches on identification and purification of phenolic compounds are required.
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