Journal
BIOORGANIC CHEMISTRY
Volume 77, Issue -, Pages 68-73Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2017.12.021
Keywords
Bio-organic catalyst; Taurine; 5-Arylidene (thio)barbituric acids, pyrano[2,3-d]pyrimidinone(thione); Water media
Funding
- Iran National Science Foundation (INSF) [96005839]
- Research Council of the University of Guilan
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Taurine, a beta-amino acid that is abundantly available in the tissues of human and animals, is efficiently used as a green bio-organic catalyst in the preparation of some of the biologically active barbituric and thiobarbituric acid derivatives. In the presence of taurine, 5-Arylidene (thio) barbituric acid derivatives were prepared via Knovenagel reaction between aldehydes and (thio)barbituric acid. Using this reagent also pyrano[2,3-d]pyrimidinone(thione) derivatives were synthesized through a three -component reaction between aldehydes, (thio)barbituric and malononitrile. Both reactions are performed in water with good to excellent yields during acceptable reaction times. No organic solvent was used during reaction or separation steps and no extra-purification was exerted. Meanwhile, reusability of taurine was easy and noticeably high. (C) 2017 Elsevier Inc. All rights reserved.
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