Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 28, Issue 15, Pages 2577-2584Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.06.021
Keywords
RNA G-quadruplex; Human telomere RNA; Small molecules; Telomere RNA structure; Telomere RNA function
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Funding
- JSPS KAKENHI [17H03091]
- Takeda Science Foundation
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Human telomeric DNA is transcribed into telomeric RNA in cells. Telomeric RNA performs the fundamental biological functions such as regulation and protection of chromosome ends. This digest highlights the human telomere RNA G-quadruplex structures, telomere RNA functions, G-quadruplex-binding small molecules, and future prospects.
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