Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 26, Issue 10, Pages 2719-2726Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.10.038
Keywords
Peptidome; Antimicrobial peptide; Anticancer peptide; Peptide libraries
Funding
- [CRC1279]
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Infectious diseases and cancers are leading causes of death and pose major challenges to public health. The human peptidome encompasses millions of compounds that display an enormous structural and functional diversity and represents an excellent source for the discovery of endogenous agents with antimicrobial and/or anticancer activity. Here, we discuss how to exploit the human peptidome for novel antimicrobial and anticancer agents through the generation of peptide libraries from human body fluids and tissues and stepwise purification of bioactive compounds. (C) 2017 Elsevier Ltd. All rights reserved.
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