Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 3, Pages -Publisher
MDPI AG
DOI: 10.3390/ijms17030323
Keywords
sepsis; cardiac dysfunction; inflammation; flavonoids; leukocytes; apigenin; mitochondria; NF-kappa B; apoptosis
Funding
- Agricultural and Food Research Initiative (AFRI) from USA Department of Agriculture National Institute of Food [2014-06654]
- OSU-Public Health Preparedness for Infectious Diseases (PHPI) fellowship
- predoctoral student ColCiencias fellowship
- [R01 HL075040-01]
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The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the identification of alternative approaches to reestablish immune balance. Apigenin, an abundant dietary flavonoid, is emerging as a potential regulator of inflammation. Here, we show that apigenin has immune-regulatory activity in vivo. Apigenin conferred survival to mice treated with a lethal dose of Lipopolysaccharide (LPS) restoring normal cardiac function and heart mitochondrial Complex I activity. Despite the adverse effects associated with high levels of splenocyte apoptosis in septic models, apigenin had no effect on reducing cell death. However, we found that apigenin decreased LPS-induced apoptosis in lungs, infiltration of inflammatory cells and chemotactic factors' accumulation, re-establishing normal lung architecture. Using NF-kappa B luciferase transgenic mice, we found that apigenin effectively modulated NF-kappa B activity in the lungs, suggesting the ability of dietary compounds to exert immune-regulatory activity in an organ-specific manner. Collectively, these findings provide novel insights into the underlying immune-regulatory mechanisms of dietary nutraceuticals in vivo.
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