4.5 Article

Hierarchical shape-by-shape assembly of microparticles for micrometer-scale viral delivery of two different genes

Journal

BIOMICROFLUIDICS
Volume 12, Issue 3, Pages -

Publisher

AMER INST PHYSICS
DOI: 10.1063/1.5030597

Keywords

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Funding

  1. National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [2015K1A4A3047345]
  2. National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning [2012M3A7A9671610, NRF-2017R1A2B4005933]
  3. Korean Health Technology R&D Project, Ministry of Health and Welfare [HI13C2162]
  4. National Research Foundation of Korea (NRF) - Ministry of Education [2017R1A6A3A04010692]
  5. Brain Korea 21 Plus Project

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Understanding tissue engineering using a bottom-up approach has been hindered by technical limitations because no platform can demonstrate the controlled formation of a heterogeneous population of cells in microscale. Here, we demonstrate hierarchical shape-by-shape assembly of virus-laden particles into larger ones to transfect two different genes on the seeded cells. We show that smaller daughter particles with different sizes and shapes can be assembled into the matching indentations of larger parent particles with different sizes and shapes. Then, we transfected a population of cells with two different gene-transfecting viruses, each of which was laden on the parent or daughter particles. Published by AIP Publishing.

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