Journal
BIOMETALS
Volume 31, Issue 3, Pages 321-330Publisher
SPRINGER
DOI: 10.1007/s10534-018-0082-x
Keywords
Cattle; Escherichia coli O157:H7; Bovine lactoferrin; Rectal administration; Shiga toxin; Interleukin 6
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Funding
- Belgian Federal Public Service of Health, Food Chain Safety and Environment [RF10/6233]
- Research Foundation Flanders (FWO Vlaanderen)
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Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle.
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