Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 97, Issue -, Pages 928-940Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.10.164
Keywords
Apoptosis; Autophagic cell death; Cancer; Chemotherapeutic agent; Combination therapy; Fisetin
Funding
- Department of Science and Technology, Science and Engineering Research Board, New Delhi, under the scheme Empowerment and Equity Opportunities for Excellence in Science [SB/EMEQ-246/2014]
- University Grants Commission - Basic Scientific Research Senior Research Fellowship (UGC-BSR-SRF) - UGC-BSR, New Delhi, India [F.7-25/2007]
- UGC-SAP DRS, New Delhi, India [II:F-3-30/2013]
- UGC-SAP DST, New Delhi, India [FIST:SR/FST/LSI-618/2014]
Ask authors/readers for more resources
During the past five decades, cancer cell lines are being successfully used as an in vitro model to discover the anticancer potential of plant secondary metabolites. Fisetin-the most popular polyphenol from fruits and vegetables, exhibits a repertoire of promising pharmacological features. Such versatile properties make fisetin an excellent anticancer agent and its efficacy as a chemotherapeutic agent against tumor heterogeneity from in vitro studies are encouraging. Fisetin is like a Pandora's box, as more research studies are being carried out, it reveals its new molecules within the cancer cells as therapeutic targets. These molecular targets orchestrate processes such as apoptosis, autophagic cell death, cell cycle, invasion, metastasis and angiogenesis in cancer cells. Besides apoptotic elicitation, fisetin's ability to induce autophagic cell death in cancer cells has been reported. This review examines the various molecular mechanisms of action elicited by fisetin leading to apoptosis and autophagic cell death as evidenced from cancer cell lines. In addition, the increased bioavailability and sustained release of fisetin improved through conjugation and enhanced effect of fisetin through synergism on various cancers are also highlighted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available