Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 103, Issue -, Pages 463-472Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.04.036
Keywords
Adult muscle stem cell; Metabolic control; Cell fate
Funding
- Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP) [2016/18633-8]
- Research Center of Redox Processes in Biomedicine (Centro de Pesquisa, Inovacao e Difusdo de Processos Redox em Biomedicina - CEPID Redoxoma) [2013/07937-8]
- Energy Metabolism Laboratory, Department of Biochemistry, Institute of Chemistry, University of Sao Paulo (USP), Sao Paulo-SP, Brazil
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Muscle stem cells or satellite cells are crucial for muscle maintenance and repair. These cells are mitotically quiescent and uniformly express the transcription factor Pax7, intermittently entering the cell cycle to give rise to daughter myogenic precursors cells and fuse with neighboring myofibers or self-renew, replenishing the stem cell pool in adult skeletal muscle. Pivotal roles of muscle stem cells in muscle repair have been uncovered, but it still remains unclear how muscle stem cell self-renewal is molecularly regulated and how muscle stem cells maintain muscle tissue homeostasis. Defects in muscle stem cell regulation to maintain/return to quiescence and self-renew are observed in degenerative conditions such as aging and neuromuscular disease. Recent works has suggested the existence of metabolic regulation and mitochondrial alterations in muscle stem cells, influencing the self-renewal commitment and function. Here I present a brief overview of recent understanding of how metabolic reprogramming governs self-renewal commitment, which is essential for conservation of muscle satellite cell pools throughout life, as well as the implications for regenerative medicine.
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