Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 98, Issue -, Pages 318-324Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.12.051
Keywords
alpha-asarone; Antioxidant; Doxorubicin; NF-kappaB; Proteinuria
Funding
- University of Mumbai, Mumbai under minor research project scheme
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alpha-asarone is natural bioactive compound that has been reported to have many benefits and medicinal properties. The present study aimed to assess the protective effect of alpha-asarone against doxorubicin (DOX) induced nephrotic syndrome in rats. An experimental nephrotic syndrome was induced by single intravenous injection of DOX (7 mg/kg) in rats. Animals were orally administered alpha-asarone (10 and 20 mg kg(-1) d(-1)) for 4 weeks. Blood, urine and kidney tissues were collected for analyses at the end of the study. Treatment with alpha-asarone significantly improved kidney function by significantly inhibiting proteinuria, hypoalbuminemia, dyslipidemia, and restored antioxidant enzyme activities in kidney tissue. Furthermore, alpha-asarone ameliorated mRNA and protein expression of NF-kappa B, TNF-alpha, IL-6, and podocin in the kidney. Histopathological evidence also confirmed the protective effects of alpha-asarone against DOX-induced nephrotic syndrome. In conclusion, alpha-asarone has an anti-nephritic effect that might be attributed to its antioxidant, hypolipidaemic and anti-inflammatory activities.
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