4.7 Article

Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models

Journal

BIOMEDICINE & PHARMACOTHERAPY
Volume 104, Issue -, Pages 679-685

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.05.081

Keywords

Non-alcoholic fatty liver disease; Liver injury; Oxidative stress; Cichoric acid

Funding

  1. One Hundred Person Project of Chinese Academy of Sciences
  2. Applied Basic Research Programs of Qinghai Province [Y229461211]
  3. Science and Technology Plan Projects in Qinghai Province [2015-ZJ-733]
  4. Jiangsu Province [BY2016-078-02]
  5. Xinjiang science and technology assistance program [2016E02067]

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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with a broad spectrum of liver injury. Oxidant stress is believed to be the pathogenesis of NAFLD as the second hit. Hydrogen peroxide is widely used as an oxidant reagent to induce the oxidant injury of cells and larval zebrafish. Recently, cichoric acid is being studied extensively for its obesity attenuating, hepatic steatosis reduction and anti-oxidant effects. In this study, to identify whether CRA could protect the H2O2 induced oxidant injury via anti-oxidant impact by using L02 and HepG2 hepatocytes as in vitro and larval zebrafish as in vivo injury models, and evaluated the protective and antioxidant effects of CRA by pretreated it on both in vitro and in vivo models. CRA was found to reduce the production of ROS and MDA, activate the anti-oxidant enzymes SOD and GSH-px, and pathways Keap1-Nrf2 and HO-1. These results demonstrated that CRA might protect the liver injury by its anti-oxidant effect, which could be a potential therapeutic agent of NAFLD.

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