Journal
BIOMATERIALS
Volume 155, Issue -, Pages 217-235Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.11.025
Keywords
Semiconducting polymer nanoparticles; Photoacoustic imaging; Molecular imaging; Phototherapy; Cancer therapy
Funding
- Nanyang Technological University (Start-Up grant) [NTU-SUG: M4081627.120]
- Singapore Ministry of Education (Academic Research Fund Tier 1) [RG133/15 M4011559]
- Singapore Ministry of Education (Academic Research Fund Tier 2) [MOE2016-T2-1-098]
- NIH [R01 DK099800, U54CA151459]
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As a new class of organic optical nanomaterials, semiconducting polymer nanoparticles (SPNs) have the advantages of excellent optical properties, high photostability, facile surface functionalization, and are considered to possess good biocompatibility for biomedical applications. This review surveys recent progress made on the design and synthesis of SPNs for molecular imaging and cancer phototherapy. A variety of novel polymer design, chemical modification and nanoengineering strategies have been developed to precisely tune up optoelectronic properties of SPNs to enable fluorescence, chemiluminescence and photoacoustic (PA) imaging in living animals. With these imaging modalities, SPNs have been demonstrated not only to image tissues such as lymph nodes, vascular structure and tumors, but also to detect disease biomarkers such as reactive oxygen species (ROS) and protein sulfenic acid as well as physiological indexes such as pH and blood glucose concentration. The potentials of SPNs in cancer phototherapy including photodynamic and photothermal therapy are also highlighted with recent examples. Future efforts should further expand the use of SPNs in biomedical research and may even move them beyond pre-clinical studies. (C) 2017 Elsevier Ltd. All rights reserved.
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