Journal
BIOMATERIALS
Volume 154, Issue -, Pages 113-133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.10.002
Keywords
3D printing; Nerve regeneration; Neurons; Glial cells; Traumatic nerve injuries; Neurodegenerative diseases
Funding
- Singapore National Research Foundation under its NMRC-CBRG grant [NMRC/CBRG/0096/2015]
- MOEAcademic Research Funding (AcRF) Tier 1 grant [RG148/14]
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Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on. the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications. Bioprinting offers a revolutionary approach for constructing repeatable and controllable 3D in vitro neural tissues with diverse cell types, complex microscale features and tissue level responses. Further advances in bioprinting research would likely consolidate existing models and generate complex neural tissue structures bearing higher fidelity, which is ultimately useful for probing disease-specific mechanisms, facilitating development of novel therapeutics and promoting neural regeneration. (C) 2017 Elsevier Ltd. All rights reserved.
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