Journal
BIOMATERIALS
Volume 157, Issue -, Pages 40-50Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.12.005
Keywords
Multifunctional biomaterials; Elastomeric nanocomposites; Polycitrate polymers; Bioactive biomaterials; Myogenic differentiation; Muscle tissue regeneration
Funding
- State Key Laboratory for Mechanical Behavior of Materials [20161801]
- Fundamental Research Funds for the Central Universities [XJJ2014090]
- Natural Science Basic Research Plan in Shaanxi Province of China [2015JQ5165]
- National Natural Science Foundation of China [51502237]
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Artificial muscle-like biomaterials have gained tremendous interests owing to their broad applications in regenerative medicine, wearable devices, bioelectronics and artificial intelligence. Unfortunately, key challenges are still existed for current materials, including biomimetic viscoelasticity, biocompatibility and biodegradation, multifunctionality. Herein, for the first time, we develop highly elastomeric, conductive and biodegradable poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites, and demonstrate their applications in myogenic differentiation and guiding skeletal muscle tissue regeneration. In PCEG nanocomposites, PCE provides the biomimetic elastomeric behavior, and the addition of reduced graphene oxide (RGO) endows the enhanced mechanical strength and conductivity. The highly elastomeric behavior, significantly enhanced modulus (400%-800%), strength (200%-300%) of PCEG nanocomposites with controlled biodegradability and electrochemical conductivity were achieved. The myoblasts proliferation and myogenic differentiation were significantly improved by PCEG nanocomposite. Significantly high in vivo biocompatibility of PCEG nanocomposites was observed when implanted in the subcutaneous tissue for 4 weeks in rats. PCEG nanocomposites could significantly enhance the muscle fibers and blood vessels formation in vivo in a skeletal muscle lesion model of rat. This study may provide a novel strategy to develop multifunctional elastomeric nanocomposites with high biocompatibility for potential soft tissue regeneration and stretchable bioelectronic devices. (C) 2017 Elsevier Ltd. All rights reserved.
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